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Thousands of imaginative scientists, over more than a century, have revealed the fascinating story of intracellular calcium, through a pathway of ingenious invention and discovery. Intracellular Calcium, the definitive book on this topic, reveals: The pathway of discovery and invention of intracellular calcium over more than 100 years. The evidence for intracellular calcium as a universal switch in all animal, plant, fungal and microbial cells How the components required for calcium signalling are named and classified. The ingenious technology, which has been developed to study intracellular calcium. How calcium is regulated inside cells and how it works to trigger an event. The role of intracellular calcium in disease, cell injury and cell death. How many drugs work through the calcium signalling system. How intracellular calcium is involved in the action of many natural toxins. How the intracellular calcium signalling system has evolved over 4000 million years, showing why it was crucial to the origin of life. A key principle presented throughout the book is the molecular variation upon which the intracellular calcium signalling system depends. This variation occurs within the same cell type and between cells with different functions, providing the invisible matrix upon which Darwin and Wallace’s Natural Selection depends. Featuring more than 100 figures, including detailed chemical structures as well as pictures of key pioneers in the field, a bibliography of more than 1500 references, as well as detailed subject and organism indices, this definitive work provides a unique source of scholarship for teachers and researchers in the biomedical sciences and beyond.


Annual Plant Reviews, Intracellular Signaling in Plants Annual Plant Reviews, Intracellular Signaling in Plants

Автор: Zhenbiao Yang

Год издания: 

Annual Plant Reviews, Volume 33 Intracellular Signaling in Plants An intriguing and important question in our understanding of plant developmental programming and responses to the environment is what kinds of strategies and mechanisms plant cells use for the transmission and the integration of various developmental and environmental signals. This book provides insight into this fundamental question in plant biology. Intracellular Signaling in Plants is an excellent new addition to the increasingly well-known and respected Annual Plant Reviews and offers the reader: • Chapters prepared by an esteemed team of international authors • A consistent and well-illustrated approach to the subject matter • An invaluable resource for all researchers and professionals in plant biochemistry and biology This important volume also deals with major known signaling mechanisms and several representative intracellular signaling networks in plants, integrating comprehensive reviews and insights from leading experts in the field. Libraries in all universities and research establishments where biological sciences are studied and taught should have copies of this essential work on their shelves. Also Available from Wiley-Blackwell Annual Plant Reviews, Volume 32 Cell Cycle Control and Plant Development Edited by Dirk Inze Print: 9781405150439 Online: 9780470988923 DOI: 10.1002/9780470988923 Annual Plant Reviews, Volume 31 Plant Mitochondria Edited by David Logan Print: 9781405149396 Online: 9780470986592 DOI: 10.1002/9780470986592


Calcium Binding Proteins Calcium Binding Proteins

Автор: Kretsinger Robert H.

Год издания: 

Calcium Binding Proteins explains the unique and highly diverse functions of calcium in biology, which are realized by calcium binding proteins. The structures and physical characteristics of these calcium binding proteins are described, as well as their functions and general patterns of their evolution. Techniques that underlie the description of proteins are discussed, including NMR, circular dichroism, optical rotatory dispersion spectroscopy, calorimetry,and crystallography. The book discusses the patterns of bochmical phenomena such as calcium homeostasis, mineralization, and cell signaling that involve specific proteins. It summarizes ongoing research and presents general hypotheses that help to focus future research, and also provides a conceptual framework and a description of the underlying techniques that permits someone entering the field to become conversant.


Fundamentals of Intracellular Calcium Fundamentals of Intracellular Calcium

Автор: Anthony K. Campbell

Год издания: 

The definitive text on the key component for cell functions—intracellular calcium This comprehensive book reveals the evidence for intracellular calcium as a universal switch in all animal, plant, fungal and microbial cells. It shows how the components required for calcium signaling are named and classified; covers the technology that has been developed to study intracellular calcium; describes how calcium is regulated inside cells and how it works to trigger an event; explains the role of intracellular calcium in disease, cell injury, and cell death; reveals how many drugs work through the calcium signaling system; and demonstrates how intracellular calcium is involved in the action of many natural toxins. The book also illustrates how the intracellular calcium signaling system has evolved over millions of years, showing why it was crucial to the origin of life. Additionally, the book promotes the importance of the molecular variation upon which the intracellular calcium signalling system depends. Featuring more than 100 figures (including detailed chemical structures as well as pictures of key pioneers in the field), a bibliography of some 1000 references, and a detailed subject index, this definitive work provides a unique source of scholarship for teachers and researchers in the biomedical sciences and beyond. Emphasizes two key scientific principles—the first to show how intracellular Ca2+ acts as a switch, to activate a wide range of cellular events, and the second demonstrating how an analogue mechanism can be superimposed on such a process Written by an internationally recognized expert in the field Filled with images and references to facilitate learning Fundamentals of Intracellular Calcium is an all-important text for post-graduate students and researchers working in biomedicine and biochemistry. It is also essential for undergraduate lecturers and their students in physiology, medicine, pharmacy, and the biosciences.


Calcium Orthophosphate-Based Bioceramics and Biocomposites Calcium Orthophosphate-Based Bioceramics and Biocomposites

Автор: Sergey V. Dorozhkin

Год издания: 

Reflecting the advances made in recent years, this is a comprehensive overview of calcium orthophosphates for bioceramics and biocomposites with a special focus on the detailed description of all those available, including their biological and geological occurrence, preparation, chemical composition, structure-property relationships and applications. In particular, the book discusses the suitability of these orthophosphates for biomedical applications and their use as bone grafts in surgery and medicine. The result is a useful reference for researchers with an academic, medical or commercial background.


Calcium Waves, Gradients and Oscillations Calcium Waves, Gradients and Oscillations

Автор: Kate Ackrill

Год издания: 

Renowned contributors provide comprehensive coverage of calcium gradients, waves and oscillations in diverse systems. Discusses the mechanisms initiating and sustaining calcium waves and their role in cell function. Describes studies using the latest techniques for measuring calcium ion gradients including chemiluminescent indicators.