Скачать книгу - Pulmonary Drug Delivery. Advances and Challenges



Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active pharmaceutical ingredient(s) (APIs), excipients and devices. This book seeks to cover some of the most pertinent issues and challenges of such formulation design associated with industrial production and desirable clinical outcome. The chapter topics have been selected with a view to integrating the factors that require consideration in the selection and design of device and formulation components which impact upon patient usability and clinical effectiveness. The challenges involved with the delivery of macromolecules by inhalation to both adult and pediatric patients are also covered. Written by leading international experts from both academia and industry, the book will help readers (formulation design scientists, researchers and post-graduate and specialized undergraduate students) develop a deep understanding of key aspects of inhalation formulations as well as detail ongoing challenges and advances associated with their development.


Human Capital. Challenges for Russia Human Capital. Challenges for Russia

Автор: В. А. Мау

Год издания: 

Education, healthcare and pension system are the key sources of modern economic growth. They stand in need of a profound transformation if they are to meet post-industrial challenges. The new principles of transformation of these sectors include individualization of services, their privatization (an increased role for private spending), life-long demand for these services, globalization (international competition) and the development of radically new technologies.


Continuous delivery. Практика непрерывных апдейтов (pdf+epub) Continuous delivery. Практика непрерывных апдейтов (pdf+epub)

Автор: Эберхард Вольф

Год издания: 



Confessions of a Successful CIO. How the Best CIOs Tackle Their Toughest Business Challenges Confessions of a Successful CIO. How the Best CIOs Tackle Their Toughest Business Challenges

Автор: Dan Roberts

Год издания: 

Be the most effective CIO you can be—by learning from the best in the business Today's Chief Information Officers must be an entirely new breed of technology leader. With ever-changing demands from the business, and in an increasingly technology-centric business environment, CIOs must find game-changing innovations and process improvements that make a real impact on the bottom line. Business executives need their CIOs to be real partners—speaking the language of the business and donning their strategist caps—not just commodity managers. Those IT leaders who fail to break out of the order-taker, utility manager mold will, simply put, be looking for a new job. In Confessions of a Successful CIO: How the Best CIOs Tackle Their Toughest Business Challenges, current and future CIOs will gain invaluable perspectives from the stories of today's best IT leaders. These acclaimed leaders—each profiled in their own chapter—explain the toughest business decision they had to make, and how the outcome influenced and impacted their leadership style. These in-depth anecdotes take the reader inside some of the most challenging business climates imaginable and chronicle how these elite CIOs made the decisions that mattered. Read detailed case studies of how some of the best CIOs have handled their most challenging business problems Learn how the best CIOs anticipate changes to their business and respond—before the business comes knocking Explore how these top-flight CIOs make critical decisions around strategy and IT to not only benefit their companies, but in some cases, to save them from becoming obsolete. Analyze their perspectives on managing people, crises and balancing the risks and rewards of their «bet the farm» strategies Confessions of a Successful CIO is the new playbook for learning how to take risks, respond to crises, and create more value from IT. Each chapter presents a different challenge, giving present-day and future IT leaders the chance to examine, analyze and learn so that they can be just as successful as the CIOs they're reading about.


The 27 Challenges Managers Face. Step-by-Step Solutions to (Nearly) All of Your Management Problems The 27 Challenges Managers Face. Step-by-Step Solutions to (Nearly) All of Your Management Problems

Автор: Bruce Tulgan

Год издания: 

For more than twenty years, management expert Bruce Tulgan has been asking, “What are the most difficult challenges you face when it comes to managing people?” Regardless of industry or job title, managers cite the same core issues—27 recurring challenges: the superstar whom the manager is afraid of losing, the slacker whom the manager cannot figure out how to motivate, the one with an attitude problem, and the two who cannot get along, to name just a few. It turns out that when things are going wrong in a management relationship, the common denominator is almost always unstructured, low substance, hit-or-miss communication. The real problem is that most managers are “managing on autopilot” without even realizing it—until something goes wrong. And if you are managing on autopilot, then something almost always does. The 27 Challenges Managers Face shows exactly how to break the vicious cycle and gain control of management relationships. No matter what the issue, Tulgan shows that the fundamentals are all you need. The very best managers hold ongoing one-on-one conversations that make expectations clear, track performance, offer feedback, and hold people accountable. For every workplace problem—even the most awkward and difficult—The 27 Challenges Managers Face shows how to tailor conversations to solve situations familiar to every manager. Tulgan offers clear approaches for turning around bad attitudes, reducing friction and conflict, improving low performers, retaining top performers, and even addressing your own personal burnout. The 27 Challenges Managers Face is an indispensable resource for managers at all levels, one anyone managing anyone will want to keep on hand. One challenge at a time, you’ll see how the most effective managers use the fundamentals of management to proactively resolve (nearly) any problem a manager could face.


Staying the Course as a CIO. How to Overcome the Trials and Challenges of IT Leadership Staying the Course as a CIO. How to Overcome the Trials and Challenges of IT Leadership

Автор: Jonathan Mitchell

Год издания: 

STAYING THE COURSE AS A CIO: HOW TO OVERCOME THE TRIALS AND CHALLENGES OF IT LEADERSHIP The shelf-life of a Chief Information Officer can be shockingly short. Few survive in post for more than a few years. More often each falls prey to insurmountable problems and their careers come to a sharp and ignominious end. In this book, a global CIO with over thirty years of experience in major corporations examines the main reasons why this happens. Readers will understand which types of issue can cause problems for an IT Leader and more importantly, they will learn strategies of how these problems can be minimized or even avoided. IT is often seen a technical backwater, but it is a discipline which has the capability to add massive value to an organisation whether it is in the private or the public sector – provided of course it has the right leadership doing the right things. Aspiring IT Leaders will need to deal with a common set of recurring trials and challenges. These include: · Overcoming the challenge of managing diverse and conflicting stakeholders · How to deal with large and complex projects · Making sense of software and how to handle the rapidly changing technology landscape · Knowing when to outsource and how to get the best out of an outsourcing partner · Harnessing the intellectual power of consultants to help you meet your goals · And last but not least, how to develop a set of strategies that are aligned with your corporate goals and then make sure your resources are properly targetted so that the IT function generates maximum positive impact for the enterprise. For IT professionals looking to fully integrate their function into the enterprise, 'Staying the Course as a CIO’ is a valuable source of practical advice, all based on real experience.