Скачать книгу - Neurodegeneration. The Molecular Pathology of Dementia and Movement Disorders



Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, ?-synuclein and TDP-43) and in the extracellular compartments (e.g. ?-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.


Mental Disorders in Epilepsy Mental Disorders in Epilepsy

Автор: B. A. Kazakovtsev

Год издания: 

The monograph shows the opportunity to study the pathogenesis of mental disorders in epilepsy based on the characteristics of its fl ow using clinical methods, structural dynamic, epidemiological and statistical analysis. Structural and dynamic analysis of the major clinical manifestations of the disease (features of personality changes, paroxysmal disorders, psychotic symptoms, dementia) held in accordance with the main patterns of development of the disease, its types and stages. On the basis of the multi-axial classifi cation of epilepsy was developed a model that allows in a retrospective analysis of an-amnestic data and clinical assessment to establish clinical and social criteria for prognosis prediction.


Voluntary Human Extinction Movement. Демотивация или же Мотивация? Пускай каждый решит это для себя сам Voluntary Human Extinction Movement. Демотивация или же Мотивация? Пускай каждый решит это для себя сам

Автор: Андрей De’мотиватор Волк

Год издания: 

Сборник материалов неопределённой формы, посвящённый глобальным (деструктивным) процессам в человеческом обществе и вытекающим отсюда последствиям.Написано в 2013—2020гг. Книга содержит нецензурную брань.


The Collected Works in Verse and Prose of William Butler Yeats. Volume 4 of 8. The Hour-glass. Cathleen ni Houlihan. The Golden Helmet. The Irish Dramatic Movement The Collected Works in Verse and Prose of William Butler Yeats. Volume 4 of 8. The Hour-glass. Cathleen ni Houlihan. The Golden Helmet. The Irish Dramatic Movement

Автор: William Butler Yeats

Год издания: 



Yellow Notes. Dementia Yellow Notes. Dementia

Автор: Maxim Mamedov

Год издания: 

“Yellow Notes” is a collection of stories about mentally ill people.The main characters are trying to live a normal life, to heal, or to understand the nature of the ailment at least.


The Lettsomian Lectures on Diseases and Disorders of the Heart and Arteries in Middle and Advanced Life [1900-1901] The Lettsomian Lectures on Diseases and Disorders of the Heart and Arteries in Middle and Advanced Life [1900-1901]

Автор: Bruce John Mitchell

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