Скачать книгу - Chemistry and Biochemistry of Oxygen Therapeutics. From Transfusion to Artificial Blood



Human blood performs many important functions including defence against disease and transport of biomolecules, but perhaps the most important is to carry oxygen – the fundamental biochemical fuel – and other blood gases around the cardiovascular system. Traditional therapies for the impairment of this function, or the rapid replacement of lost blood, have centred around blood transfusions. However scientists are developing chemicals (oxygen therapeutics, or “blood substitutes”) which have the same oxygen-carrying capability as blood and can be used as replacements for blood transfusion or to treat diseases where oxygen transport is impaired. Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood links the underlying biochemical principles of the field with chemical and biotechnological innovations and pre-clinical development. The first part of the book deals with the chemistry, biochemistry, physiology and toxicity of oxygen, including chapters on hemoglobin reactivity and regulation; the major cellular and physiological control mechanisms of blood flow and oxygen delivery; hemoglobin and myoglobin; nitric oxide and oxygen; and the role of reactive oxygen and nitrogen species in ischemia/reperfusion Injury. The book then discusses medical needs for oxygen supply, including acute traumatic hemorrhage and anemia; diagnosis and treatment of haemorrhages in «non-surgical» patients; management of perioperative bleeding; oxygenation in the preterm neonate; ischemia normobaric and hyperbaric oxygen therapy for ischemic stroke and other neurological conditions; and transfusion therapy in ? thalassemia and sickle cell disease Finally “old”and new strategies for oxygen supply are described. These include the political, administrative and logistic issues surrounding transfusion; conscientious objection in patient blood management; causes and consequences of red cell incompatibility; biochemistry of red blood cell storage; proteomic investigations on stored red blood cells; red blood cells from stem cells; the universal red blood cell; allosteric effectors of hemoglobin; hemoglobin-based oxygen carriers; oxygen delivery by natural and artificial oxygen carriers; cross-linked and polymerized hemoglobins as potential blood substitutes; design of novel pegylated hemoglobins as oxygen carrying plasma expanders; hb octamers by introduction of surface cysteines; hemoglobin-vesicles as a cellular type hemoglobin-based oxygen carrier; animal models and oxidative biomarkers to evaluate pre-clinical safety of extracellular hemoglobins; and academia – industry collaboration in blood substitute development. Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood is an essential reference for clinicians, haematologists, medicinal chemists, biochemists, molecular biologists, biotechnologists and blood substitute researchers.


Color Atlas of Biochemistry Color Atlas of Biochemistry

Автор: Jan Koolman

Год издания: 

Second edition, enlarged and revised with 215 color plates. This Thieme Flexibook presents the fundamentals of human and mammalian biochemistry in 192 stunning color plates. Key features include the unique combination of highly effective color graphics and comprehensive figure legends. Unified color-coding of atoms, coenzymes, chemical classes, and cell organelles allows quick recognition of all involved systems, and computer graphics provide simulated 3D representation of many important molecules. This Flexibook is ideal for students of all levels with its complete coverage of the structure and composition of biologically relevant molecules and their metabolism


Chemistry in questions and tests: учебное пособие Chemistry in questions and tests: учебное пособие

Автор: М. Н. Милеева

Год издания: 



Harry Potter and the Half-Blood Prince Harry Potter and the Half-Blood Prince

Автор: Дж. К. Роулинг

Год издания: 

"There it was, hanging in the sky above the school: the blazing green skull with a serpent tongue, the mark Death Eaters left behind whenever they had entered a building… wherever they had murdered…" When Dumbledore arrives at Privet Drive one summer night to collect Harry Potter, his wand hand is blackened and shrivelled, but he does not reveal why. Secrets and suspicion are spreading through the wizarding world, and Hogwarts itself is not safe. Harry is convinced that Malfoy bears the Dark Mark: there is a Death Eater amongst them. Harry will need powerful magic and true friends as he explores Voldemort's darkest secrets, and Dumbledore prepares him to face his destiny… Pottermore has now launched the Wizarding World Book Club. Visit Pottermore to sign up and join weekly Twitter discussions at WW Book Club.


A system of chemistry. Vol. 2 A system of chemistry. Vol. 2

Автор: Thomas Thomson

Год издания: 

Полный вариант заголовка: «A system of chemistry: in 5 volumes by Thomas Thomson Vol. 2».


A system of chemistry. Vol. 5 A system of chemistry. Vol. 5

Автор: Thomas Thomson

Год издания: 

Полный вариант заголовка: «A system of chemistry : Vol. 5 : in 5 volumes / by Thomas Thomson».