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Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA – quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes – sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis – aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis – ?-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.


Trust Agents. Using the Web to Build Influence, Improve Reputation, and Earn Trust Trust Agents. Using the Web to Build Influence, Improve Reputation, and Earn Trust

Автор: Chris Brogan

Год издания: 

The New York Times and Wall Street Journal bestseller-now in a new, updated paperback edition Today's online influencers are Web natives who trade in trust, reputation, and relationships, using social media to accrue the influence that builds up or brings down businesses online. In Trust Agents, two social media veterans show you how to tap into the power of social networks to build your brand's influence, reputation, and, of course, profits. In this revised paperback version, learn how businesses are using the latest online social tools to build networks of influence and how you can use those networks to positively impact your business. Combining high-level theory and practical actions, this guide delivers actionable steps and case studies that show how social media can positively impact your business. New edition features specific first moves for entering social media for small businesses, educators, travel and hospitality enterprises, nonprofit organizations, and corporations Authors both have a major presence on the social Web as well as years of online marketing and new media experience If you want your business to succeed, don't sit on the sidelines while new markets and channels grow. Instead, use the Web to build trust with your consumers using Trust Agents.


Emerging Infectious Diseases. A Guide to Diseases, Causative Agents, and Surveillance Emerging Infectious Diseases. A Guide to Diseases, Causative Agents, and Surveillance

Автор: Lisa Beltz A.

Год издания: 

Emerging Infectious Diseases offers an introduction to emerging and reemerging infectious disease, focusing on significant illnesses found in various regions of the world. Many of these diseases strike tropical regions or developing countries with particular virulence, others are found in temperate or developed areas, and still other microbes and infections are more indiscriminate. This volume includes information on the underlying mechanisms of microbial emergence, the technology used to detect them, and the strategies available to contain them. The author describes the diseases and their causative agents that are major factors in the health of populations the world over. The book contains up-to-date selections from infectious disease journals as well as information from the Centers for Disease Control and Prevention, the World Health Organization, MedLine Plus, and the American Society for Microbiology. Perfect for students or those new to the field, the book contains Summary Overviews (thumbnail sketches of the basic information about the microbe and the associated disease under examination), Review Questions (testing students' knowledge of the material), and Topics for Further Discussion (encouraging a wider conversation on the implications of the disease and challenging students to think creatively to develop new solutions). This important volume provides broad coverage of a variety of emerging infectious diseases, of which most are directly important to health practitioners in the United States.


Antiparasitic and Antibacterial Drug Discovery. From Molecular Targets to Drug Candidates Antiparasitic and Antibacterial Drug Discovery. From Molecular Targets to Drug Candidates

Автор: Paul Selzer M.

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Addressing parasitic diseases and those caused by bacteria, this much needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.


Aryl Diazonium Salts. New Coupling Agents and Surface Science Aryl Diazonium Salts. New Coupling Agents and Surface Science

Автор: Mohamed Chehimi Mehdi

Год издания: 

Diazonium compounds are employed as a new class of coupling agents to link polymers, biomacromolecules, and other species (e. g. metallic nanoparticles) to the surface of materials. The resulting high performance materials show improved chemical and physical properties and find widespread applications. The advantage of aryl diazonium salts compared to other surface modifiers lies in their ease of preparation, rapid (electro)reduction, large choice of reactive functional groups, and strong aryl-surface covalent bonding. This unique book summarizes the current knowledge of the surface and interface chemistry of aryl diazonium salts. It covers fundamental aspects of diazonium chemistry together with theoretical calculations of surface-molecule bonding, analytical methods used for the characterization of aryl layers, as well as important applications in the field of electrochemistry, nanotechnology, biosensors, polymer coatings and materials science. Furthermore, information on other surface modifiers (amines, silanes, hydrazines, iodonium salts) is included. This collection of 14 self-contained chapters constitutes a valuable book for PhD students, academics and industrial researchers working on this hot topic.


Constructive Dialogue Modelling. Speech Interaction and Rational Agents Constructive Dialogue Modelling. Speech Interaction and Rational Agents

Автор: Kristiina Jokinen

Год издания: 

Dialogue management technology has developed rapidly over the years resulting in real-time applications like telephony directories, timetable enquiries, and in-car applications. However, the current technology is still largely based on models that use rigid command language type interactions, and the users need to adapt their human communication strategies to the needs of the technology. As an increasing number of interactive ubiquitous applications will appear, challenges for interaction technology concern especially natural, more human-friendly communication. Recent research has focused on developing speech-based interactive systems that aim to increase the system’s communicative competence. By including aspects of interaction beyond simple speech recognition and question-answer based interaction, applications with more conversational interfaces have become possible. New dialogue management technology needs to address the challenges in human-technology interaction, so that smart environments should not only enable user-controlled command interfaces but equip applications with a capability that affords easy and friendly interactions with the user. Dialogue Modelling: Speech Interaction and Rational Agents provides an overview of the current dialogue technology and research trends in spoken dialogue systems, presenting a coherent perspective of AI-based cooperative interaction management. The book complements existing research regarding human-computer interfaces, speech and language technology, and communication studies in general, bringing different view-points together and integrating them into a single point of reference. Constructive Dialogue Modelling: Presents a guide to spoken dialogue technology and current research trends. Provides an overview of human factors in dialogue systems and delivers a new metaphor for human-computer interaction and computer as agent. Explains the architecture of dialogue systems using examples from systems such as Interact and DUMAS Offers a comprehensive overview of original research into the new trends in speech dialogue technology in light of innovations such as ubiquitous computing. This book will provide essential reading for industrial designers and interface engineers, university researchers and teachers, computer scientists, human communication researchers, speech and language technologists, cognitive engineers/cognitive scientists, as well as social and media researchers, and psychologists. Advanced students and researchers in computer science, speech and language technologies, psychology and communication research will find this text of interest.