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Instrumental techniques for analyzing intrinsically disordered proteins The recently recognized phenomenon of protein intrinsic disorder is gaining significant interest among researchers, especially as the number of proteins and protein domains that have been shown to be intrinsically disordered rapidly grows. The first reference to tackle this little-documented area, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation provides researchers with a much-needed, comprehensive summary of recent achievements in the methods for structural characterization of intrinsically disordered proteins (IDPs). Chapters discuss: Assessment of IDPs in the living cell Spectroscopic techniques for the analysis of IDPs, including NMR and EPR spectroscopies, FTIR, circular dichroism, fluorescence spectroscopy, vibrational methods, and single-molecule analysis Single-molecule techniques applied to the study of IDPs Assessment of IDP size and shape Tools for the analysis of IDP conformational stability Mass spectrometry Approaches for expression and purification of IDPs With contributions from an international selection of leading researchers, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation fills an important need in a rapidly growing field. It is required reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, physiologists, and specialists in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.

Comprehensive coverage of the foundations, applications, recent developments, and future of conformal differential geometry Conformal Differential Geometry and Its Generalizations is the first and only text that systematically presents the foundations and manifestations of conformal differential geometry. It offers the first unified presentation of the subject, which was established more than a century ago. The text is divided into seven chapters, each containing figures, formulas, and historical and bibliographical notes, while numerous examples elucidate the necessary theory. Clear, focused, and expertly synthesized, Conformal Differential Geometry and Its Generalizations * Develops the theory of hypersurfaces and submanifolds of any dimension of conformal and pseudoconformal spaces. * Investigates conformal and pseudoconformal structures on a manifold of arbitrary dimension, derives their structure equations, and explores their tensor of conformal curvature. * Analyzes the real theory of four-dimensional conformal structures of all possible signatures. * Considers the analytic and differential geometry of Grassmann and almost Grassmann structures. * Draws connections between almost Grassmann structures and web theory. Conformal differential geometry, a part of classical differential geometry, was founded at the turn of the century and gave rise to the study of conformal and almost Grassmann structures in later years. Until now, no book has offered a systematic presentation of the multidimensional conformal differential geometry and the conformal and almost Grassmann structures. After years of intense research at their respective universities and at the Soviet School of Differential Geometry, Maks A. Akivis and Vladislav V. Goldberg have written this well-conceived, expertly executed volume to fill a void in the literature. Dr. Akivis and Dr. Goldberg supply a deep foundation, applications, numerous examples, and recent developments in the field. Many of the findings that fill these pages are published here for the first time, and previously published results are reexamined in a unified context. The geometry and theory of conformal and pseudoconformal spaces of arbitrary dimension, as well as the theory of Grassmann and almost Grassmann structures, are discussed and analyzed in detail. The topics covered not only advance the subject itself, but pose important questions for future investigations. This exhaustive, groundbreaking text combines the classical results and recent developments and findings. This volume is intended for graduate students and researchers of differential geometry. It can be especially useful to those students and researchers who are interested in conformal and Grassmann differential geometry and their applications to theoretical physics.

How the amino acid sequence of a protein determines its three-dimensional structure is a major problem in biology and chemistry. Leading experts in the fields of NMR spectroscopy, X-ray crystallography, protein engineering and molecular modeling offer provocative insights into current views on the protein folding problem and various aspects for future progress.

This is the first comprehensive treatment of conformal antenna arrays from an engineering perspective. While providing a thorough foundation in theory, the authors of this publication provide a wealth of hands-on instruction for practical analysis and design of conformal antenna arrays. Thus, you get the knowledge you need, alongside the practical know-how to design antennas that are integrated into such structures aircrafts or skyscrapers.