Скачать книгу - Detour

Success comes in many forms and in synthesis it can be a failure that results in their ultimate successful solutions. This long-awaited sequel to «Dead Ends and Detours» retains the proven concept while featuring over 20 new case studies of failed strategies and their (successful) solutions in natural product total synthesis. Additionally, computational models are used to discuss the problem in much more detail and to provide readers with additional information not found in the primary literature. The topics range from classic synthetic reactions (e.g. Diels Alder reaction), metal-mediated coupling reactions, metathesis, and asymmetric catalysis to the importance of protecting and activating groups. This book will benefit not only graduate students in organic chemistry but also advanced researchers as they gain knowledge derived from the step-by-step analysis of mistakes made in the past and, thus be able to improve their own chemical reaction planning. With its coverage of the most commonly applied reaction types, the book perfectly complements its predecessor, which focuses on general aspects, such as reactivity and selectivity.

Drive me to distraction!Okay, so there are some cliches that are true–rolling stones gathering no moss and the grass is greener are two that come to mind…mainly because I'm stuck in a ditch next to a sinfully gorgeous and far too stubborn man who won't allow himself to smell the roses. (Yes, I know. It's another true one.)But I've learned that the kindness of strangers can lead to some pleasant surprises, if not actual happiness. So that (along with a fear of flying and a pesky judge who took away my license) is how I found myself driving cross-country to a friend's wedding with the groom's best friend.Hmm. Best friend? Isn't there something about that I should remember…?

From the Justice Department’s memos defending coerced interrogation to Alberto Gonzales’ firing of U.S. Attorneys who did not fit the Bush Administration’s political needs, Law’s Detour paints an alarming picture of the many detours that George W. Bush and his allies created to thwart transparency and undermine the rule of law after September 11, 2001. Pursuing those detours, Bush officials set up a law-free zone at Guantánamo, ordered massive immigration raids that separated families, and screened candidates for civil service jobs to ensure the hiring of “real Americans.”While government needs flexibility to address genuine risks to national security—which certainly exist in the post-9/11 world—the Bush Administration’s use of detours distracted the government from urgent priorities, tarnished America’s reputation, and threatened voting and civil rights. In this comprehensive analysis of Bush officials’ efforts to stretch and strain the justice system, Peter Margulies canvasses the costs of the Administration’s many detours, from resisting accountability in the war on terrorism to thwarting economic and environmental regulation. Concise and full of compelling anecdotes, Law’s Detour maps these aberrations, surveys the damage done, and reaffirms the virtues of transparency and dialog that the Bush administration dismissed.