Скачать книгу - The Enteric Microbiota

The Human Microbiota offers a comprehensive review of all human-associated microbial niches in a single volume, focusing on what modern tools in molecular microbiology are revealing about human microbiota, and how specific microbial communities can be associated with either beneficial effects or diseases. An excellent resource for microbiologists, physicians, infectious disease specialists, and others in the field, the book describes the latest research findings and evaluates the most innovative research approaches and technologies. Perspectives from pioneers in human microbial ecology are provided throughout.

This book discusses the community of microbial species (the microbiota, microbiome), which inhabits the large bowel of humans. Written from the perspective of an academic who has been familiar with the topic for 40 years, it provides a long-term perspective of knowledge about this high profile and fast-moving topic. Building on general ecological principles, the book aims to help the reader to understand how the microbiota is formed, how it works, and what the consequences are to humans. Understanding the Gut Microbiota focuses on conceptual progress made from studies of the human bowel microbiota. Where appropriate, it draws on knowledge obtained from other animal species to provide conceptual enlightenment, but this is essentially a book about humans and their bowel microbes. Particular research approaches are recommended to fill knowledge gaps so that fundamental ecological theory and information about the microbiota can be translated into benefits for human health. The relationship between food for humans and resulting food for bowel bacteria emerges as an important topic for consideration. This concise scholarly treatise of the microbiota of the human bowel will be of great interest and use as a text and reference work for professionals, teachers and students across a wide range of disciplines, including the health sciences, general biology, and food science and technology. The provision of handy ‘explanation of terms’ means that those with a general interest in science can also read the book with enjoyment.

Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.

Over the last few years there have been huge advances made in our understanding of the interactions between the brain and the gut – the enteric nervous system. This book is particularly relevant in the understanding, diagnosis and management of irritable bowel syndrome – the most common functional disorder of the bowel. IBS has been diagnosed in 10-20% of adults in the US, and symptoms of IBS are responsible for more than 3 million visits to the physician in the US. This book is aimed at specialist gastroenterologists but also should be of interest for trainees and fellows in gastroenterology, as well as PCPs and GPs with an interest in this subject.

Covers all aspects of the structure, function, neurochemistry, transmitter identification and development of the enteric nervous system This book brings together extensive knowledge of the structure and cell physiology of the enteric nervous system and provides an up-to-date synthesis of the roles of the enteric nervous system in the control of motility, secretion and blood supply in the gastrointestinal tract. It includes sections on the enteric nervous system in disease, genetic abnormalities that affect enteric nervous system function, and targets for therapy in the enteric nervous system. It also includes many newly created explanatory diagrams and illustrations of the organization of enteric nerve circuits. This new book is ideal for gastroenterologists (including trainees/fellows), clinical physiologists and educators. It is invaluable for the many scientists in academia, research institutes and industry who have been drawn to work on the gastrointestinal innervation because of its intrinsic interest, its economic importance and its involvement in unsolved health problems. It also provides a valuable resource for undergraduate and graduate teaching.