Скачать книгу - Computational Prediction of Protein Complexes from Protein Interaction Networks



Complexes of physically interacting proteins constitute fundamental functional units that drive almost all biological processes within cells. A faithful reconstruction of the entire set of protein complexes (the «complexosome») is therefore important not only to understand the composition of complexes but also the higher level functional organization within cells. Advances over the last several years, particularly through the use of high-throughput proteomics techniques, have made it possible to map substantial fractions of protein interactions (the «interactomes») from model organisms including Arabidopsis thaliana (a flowering plant), Caenorhabditis elegans (a nematode), Drosophila melanogaster (fruit fly), and Saccharomyces cerevisiae (budding yeast). These interaction datasets have enabled systematic inquiry into the identification and study of protein complexes from organisms. Computational methods have played a significant role in this context, by contributing accurate, efficient, and exhaustive ways to analyze the enormous amounts of data. These methods have helped to compensate for some of the limitations in experimental datasets including the presence of biological and technical noise and the relative paucity of credible interactions. In this book, we systematically walk through computational methods devised to date (approximately between 2000 and 2016) for identifying protein complexes from the network of protein interactions (the protein-protein interaction (PPI) network). We present a detailed taxonomy of these methods, and comprehensively evaluate them for protein complex identification across a variety of scenarios including the absence of many true interactions and the presence of false-positive interactions (noise) in PPI networks. Based on this evaluation, we highlight challenges faced by the methods, for instance in identifying sparse, sub-, or small complexes and in discerning overlapping complexes, and reveal how a combination of strategies is necessary to accurately reconstruct the entire complexosome.


Les predictions de Jean Gorani, citoyen francais, sur la revolution de France Les predictions de Jean Gorani, citoyen francais, sur la revolution de France

Автор: Jean Gorani

Год издания: 

Полный вариант заголовка: «Les predictions de Jean Gorani, citoyen francais, sur la Revolution de France».


Focus on Oral Interaction Focus on Oral Interaction

Автор: Jenefer Philp

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Explores the role of oral interaction for second language learning from cognitive, social, pedagogical and linguistic perspectives, with a focus on research relevant to English language learners aged 5-18 in a variety of classroom contexts.


Evil by Design. Interaction Design to Lead Us into Temptation Evil by Design. Interaction Design to Lead Us into Temptation

Автор: Chris Nodder

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How to make customers feel good about doing what you want Learn how companies make us feel good about doing what they want. Approaching persuasive design from the dark side, this book melds psychology, marketing, and design concepts to show why we’re susceptible to certain persuasive techniques. Packed with examples from every nook and cranny of the web, it provides easily digestible and applicable patterns for putting these design techniques to work. Organized by the seven deadly sins, it includes: Pride – use social proof to position your product in line with your visitors’ values Sloth – build a path of least resistance that leads users where you want them to go Gluttony – escalate customers’ commitment and use loss aversion to keep them there Anger – understand the power of metaphysical arguments and anonymity Envy – create a culture of status around your product and feed aspirational desires Lust – turn desire into commitment by using emotion to defeat rational behavior Greed – keep customers engaged by reinforcing the behaviors you desire Now you too can leverage human fallibility to create powerful persuasive interfaces that people will love to use – but will you use your new knowledge for good or evil? Learn more on the companion website, evilbydesign.info.


Advanced Penetration Testing. Hacking the World's Most Secure Networks Advanced Penetration Testing. Hacking the World's Most Secure Networks

Автор: Wil Allsopp

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Build a better defense against motivated, organized, professional attacks Advanced Penetration Testing: Hacking the World's Most Secure Networks takes hacking far beyond Kali linux and Metasploit to provide a more complex attack simulation. Featuring techniques not taught in any certification prep or covered by common defensive scanners, this book integrates social engineering, programming, and vulnerability exploits into a multidisciplinary approach for targeting and compromising high security environments. From discovering and creating attack vectors, and moving unseen through a target enterprise, to establishing command and exfiltrating data—even from organizations without a direct Internet connection—this guide contains the crucial techniques that provide a more accurate picture of your system's defense. Custom coding examples use VBA, Windows Scripting Host, C, Java, JavaScript, Flash, and more, with coverage of standard library applications and the use of scanning tools to bypass common defensive measures. Typical penetration testing consists of low-level hackers attacking a system with a list of known vulnerabilities, and defenders preventing those hacks using an equally well-known list of defensive scans. The professional hackers and nation states on the forefront of today's threats operate at a much more complex level—and this book shows you how to defend your high security network. Use targeted social engineering pretexts to create the initial compromise Leave a command and control structure in place for long-term access Escalate privilege and breach networks, operating systems, and trust structures Infiltrate further using harvested credentials while expanding control Today's threats are organized, professionally-run, and very much for-profit. Financial institutions, health care organizations, law enforcement, government agencies, and other high-value targets need to harden their IT infrastructure and human capital against targeted advanced attacks from motivated professionals. Advanced Penetration Testing goes beyond Kali linux and Metasploit and to provide you advanced pen testing for high security networks.


The Executive's Guide to Enterprise Social Media Strategy. How Social Networks Are Radically Transforming Your Business The Executive's Guide to Enterprise Social Media Strategy. How Social Networks Are Radically Transforming Your Business

Автор: Mike Barlow

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Social media has already transformed society. Now it is poised to revolutionize communications and collaborative business processes. This book provides you with an actionable framework for developing and executing successful enterprise social networking strategies. Using straightforward language, accompanied by exhibits and fleshed out with real-world stories and revealing anecdotes, you will learn how to develop your own internal corporate social media strategy. Through the use of in-depth interviews with leading companies using these strategies, you will also discover best practices that will propel your business to new heights.