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Extractive metallurgy is the art and science of extracting metals from their ores and refining them. The production of metals and alloys from these source materials is still one of the most important and fundamental industries in both developed and developing economies around the world. The outputs and products are essential resources for the metallic, mechanical, electromagnetic, electrical and electronics industries (silicon is treated as a metal for these purposes). This series is devoted to the extraction of metals from ores, concentrates (enriched ores), scraps, and other sources and their refining to the state of either liquid metal before casting or to solid metals. The extraction and refining operations that are required may be carried out by various metallurgical reaction processes. Extractive Metallurgy 1 deals with the fundamentals of thermodynamics and kinetics of the reaction processes. Extractive Metallurgy 2 focuses on pyrometallurgical, hydrometallurgical, halide and electro-metallurgical (conversion) processes. Extractive Metallurgy 3 deals with the industrial processing operations, technologies, and process routes, in other words the sequence of steps or operations used to convert the ore to metal. Processes and operations are studied using the methodology of “chemical reaction engineering”. As the fundamentals of the art and science of Extractive Metallurgy are infrequently taught as dedicated university or engineering schools courses, this series is intended both for students in the fields of Metallurgy and Mechanical Engineering who want to acquire this knowledge, and also for engineers put in charge of the operation of an industrial production unit or the development of a new process, who will need the basic knowledge of the corresponding technology.

There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for «greener» processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

The focus of early drug development has been the submission of an Investigational New Drug application to regulatory agencies. Early Drug Development: Strategies and Routes to First-in-Human Trials guides drug development organizations in preparing and submitting an Investigational New Drug (IND) application. By explaining the nuts and bolts of preclinical development activities and their interplay in effectively identifying successful clinical candidates, the book helps pharmaceutical scientists determine what types of discovery and preclinical research studies are needed in order to support a submission to regulatory agencies.

Nonlinear problems are of interest to engineers, physicists and mathematicians and many other scientists because most systems are inherently nonlinear in nature. As nonlinear equations are difficult to solve, nonlinear systems are commonly approximated by linear equations. This works well up to some accuracy and some range for the input values, but some interesting phenomena such as chaos and singularities are hidden by linearization and perturbation analysis. It follows that some aspects of the behavior of a nonlinear system appear commonly to be chaotic, unpredictable or counterintuitive. Although such a chaotic behavior may resemble a random behavior, it is absolutely deterministic. Analytical Routes to Chaos in Nonlinear Engineering discusses analytical solutions of periodic motions to chaos or quasi-periodic motions in nonlinear dynamical systems in engineering and considers engineering applications, design, and control. It systematically discusses complex nonlinear phenomena in engineering nonlinear systems, including the periodically forced Duffing oscillator, nonlinear self-excited systems, nonlinear parametric systems and nonlinear rotor systems. Nonlinear models used in engineering are also presented and a brief history of the topic is provided. Key features: Considers engineering applications, design and control Presents analytical techniques to show how to find the periodic motions to chaos in nonlinear dynamical systems Systematically discusses complex nonlinear phenomena in engineering nonlinear systems Presents extensively used nonlinear models in engineering Analytical Routes to Chaos in Nonlinear Engineering is a practical reference for researchers and practitioners across engineering, mathematics and physics disciplines, and is also a useful source of information for graduate and senior undergraduate students in these areas.

The stunning debut of a talented young travel writer.‘South from Barbary’ – as 19th-century Europeans knew North Africa – is the compelling account of Justin Marozzi’s 1,500-mile journey by camel along the slave-trade routes of the Libyan Sahara.Marozzi and his travelling companion Ned had never travelled in the desert, nor had they ridden camels before embarking on this expedition. Encouraged by a series of idiosyncratic Tuareg and Tubbu guides, they learnt the full range of desert survival skills, including how to master their five faithful camels.The caravan of two explorers, five camels with distinctive personalities and their guides undertook a gruelling journey across some of the most inhospitable territory on earth. Despite threats from Libyan officialdom and the ancient, natural hardships of the desert, Marozzi and Ned found themselves growing ever closer to the land and its people.More than a travelogue, ‘South from Barbary’ is a fascinating history of Saharan exploration and efforts by early British explorers to suppress the African slave trade. It evokes the poetry and solitude of the desert, the companionship of man and beast, the plight of a benighted nation, and the humour and generosity of its resilient people.Written with infectious wit and insight, and a terrific historical grasp, this is a superbly readable travel book about a rarely visited but enthralling and immensely beautiful region of the world.