The Agile Approach to Adaptive Research. Optimizing Efficiency in Clinical Development
Автор: Ekins Sean
Год издания: 0000
Apply adaptive research to improve results in drug development The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a solution. It outlines how adaptive research, using already-available tools and techniques, can enable the industry to streamline clinical trials and reach decision points faster and more efficiently. With a wealth of real-world cases and examples, author Michael Rosenberg gives readers a practical overview of drug development, the problems inherent in current practices, and the advantages of adaptive research technology and methods. He explains the concepts, principles, and specific techniques of adaptive research, and demonstrates why it is an essential evolutionary step toward improving drug research and development. Chapters explore such subjects as: The adaptive concept Design and operational adaptations Sample-size reestimation Agile clinical development Safety and dose finding Statistics in adaptive research, including frequentist and Bayesian approaches Data management technologies The future of clinical development By combining centuries-old intellectual foundations, recent technological advances, and modern management techniques, adaptive research preserves the integrity and validity of clinical research but dramatically improves efficiency.
Web Application
Development with PHP 4.0
Автор: Tobias Ratschiller, Till Gerken
Год издания:
While the success of Open Source software like Linux or Apache has been documented
extensively throughout all mainstream media, the rise of PHP has gone largely
unnoticed. Still, the Web scripting language PHP is the most popular module for the
Apache Web server, according to an E-Soft survey (www.e-softinc.com/survey/).
Netcraft studies have found that PHP is in use on over 6% of all Web domains in the
world (see www.netcraft.com/survey).That’s an incredible market penetration for a
rather specialized product.This popularity continues to rise exponentially. Increasingly,
this is being reflected in traditional media: As of May, 2000, more than 20 books about
PHP have been published in different languages, with more in the pipeline.
Commercial players are beginning to join the bandwagon: PHP is included with
Web servers, for example C2’s Stronghold, and Linux distributions. A new company,
Zend Technologies, has been formed to provide commercial add-ons and support for
PHP.A long list of large-scale Web sites employ PHP, as well as hundreds of thousands
of small to medium Web sites.
Secure PHP Development: Building 50 Practical Applications
Автор: Mohammed J. Kabir
Год издания:
The personal home page (PHP) server-side scripting language is particular well adapted to connecting HTML-based web pages to a backend database for dynamic content. This book explains the entire nuts-and-bolts process of the PHP application life cycle: requirements, design, development, maintenance and tuning. It shows how PHP can be used to design and develop highly manageable and secure applications to solve practical problems.
Mercedes C-klasse (W204) / C 180 Kompressor / C 180 Kompressor BlueEfficiency / C 200 Kompressor / CDI / C 220 CDI / C 230 / C 250 CDI / C 280 / C 300 / C 320 / C 350 from 2007 (+ upgrade in 2011), bo
Автор: Монолит
Год издания:
Content
Actions in emergency situations
- Location of on-board tools and equipment
- Damage to the tire
- Starting the engine from an external battery
- Towing a car
- Fuses
Daily checks and troubleshooting
The instruction on operation and maintenance service of the car
- Technical information of the car
- Controls, dashboard, interior equipment
- Caring for the body and the car
- Car maintenance
Precautions and safety rules when working on a car
Basic tools, measuring instruments and methods of working with them
- Basic set of necessary tools
- Methods of working with measuring devices
The mechanical part of the engine (gasoline engines)
- Car service
- Engine removal
- V-belt drive for auxiliary equipment
- Gas distribution mechanism
- Cylinder head
- Cylinder block
- Crankshaft
- Service data and specification
The mechanical part of the engine (diesel engines)
- Car service
- Engine removal
- V-belt drive for auxiliary equipment
- Gas distribution mechanism
- Cylinder head
- Cylinder block
- Crankshaft
- Service data and specification
Cooling system
- General information
- Car service
- Coolant pump, thermostat
- Radiator
- Fan
- Expansion tank and coolant level sensor (M271 and M272 engines)
- Service data and specification
Lubrication system
- Oil change in engine and oil filter (all engines)
- Oil pan
- Oil pump
- Oil filter, heat exchanger
- Oil sensors
- Service data and specification
Power system
- Precautions for repair
- Power system for petrol engines
- Power system for diesel engines
- Service data and specification
Engine management system
- Accelerator pedal
- Electronic engine control unit
- Various sensors
- Service data and specification
The intake and exhaust system
- Intake manifold
- Release system
- Air pressure system
- Service data and specification
Engine electrical equipment
- General information
- Ignition system (petrol engines)
- Preheating system (diesel engines)
- Engine start system
- Charge system
- Service data and specification
Clutch
- Car service
- Precautions for repair
- Clutch
- Clutch drive
- Clutch pedal
- Service data and specification
Manual transmission
- Car service
- Removing and installing gearbox
- Gearbox disassembly
- Gear shift mechanism
- Service data and specification
Automatic transmission
- Car service
- Removing and installing gearbox
- Elements of the gearbox
- Gear shift mechanism
- Transfer case
- Service data and specification
Drive shafts and final drive
- Car service
- Drive of front wheels (cars with 4MATIC system)
- Drive of rear wheels
- Cardan shaft
- Service data and specification
Suspension
- Precautions for repair
- Front suspension
- Rear suspension
- Wheels and tires
- Service data and specification
Brake system
- Information on repairing the brake system
- Car service
- Components of the braking system
- Front brakes
- Rear brakes
- Parking brake system
- Anti-lock braking system (ABS)
- Service data and specification
Steering
- Car service
- Steering wheel, steering column
- Steering gear
- Steering links
- Power steering
- Service data and specification
Body
- General information
- Interior
- Exterior
- Clearances in the body panels
- Service data and specification
Passive safety system
- General information
- Passive safety control unit
- Airbag modules
- Impact sensors
- Seat belts
- Service data and specification
- Disposal of airbag and belt tensioner modules
Air conditioning, ventilation and heating system
- General information
- Ventilation and heating system
- Automatic heating system
- Air conditioning system
- Service data and specification
Electroschemes
- How to read and use the circuit diagram
- List of abbreviations in diagrams
- Electroschemes
Explanatory dictionary
Английский язык для профессионального развития. Ресторанный и кейтеринговый бизнес / English for Professional Development. Restaurant and Catering Business