Найти книгу: "Enzyme Inhibition in Drug Discovery and Development. The Good and the Bad"

The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development. With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the «good» inhibitions—desirable pharmacological effects—and «bad» inhibitions—drug–drug interactions and toxicity. The book discusses: The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.

Полный вариант заголовка: «The history of the discovery and conquest of the Canary Islands : translated from a Spanish manuscript, lately found in the island of Palma : with an enquiry into the origin of the ancient inhabitants : to which is added, a dsescription of the Canary Islands, including the modern history of the inhabitants, and an account of their manners, customs, trade, & c. / by George Glas».

Представлены статьи, в которых рассматриваются макроэкономические проблемы современной экономики, современные особенности развития экономики в условиях рецессии мировых рынков, проблемы и перспективы развития финансового сектора в условиях международной экономической нестабильности, возможности инновационного развития российской экономики, современные тенденции в управлении, информационные технологии в экономике, социальные и правовые проблемы рыночной экономики, социально-экономическая и экологическая ответственность бизнеса в свете обеспечения устойчивого развития. Для научных сотрудников, преподавателей, аспирантов и студентов вузов экономических и гуманитарных специальностей, а также всех, кто интересуется актуальными проблемами состояния и развития экономического анализа, а также современными тенденциями развития национальной и мировой экономики.