Найти книгу: "Ligand-Binding Assays. Development, Validation, and Implementation in the Drug Development Arena"

A consolidated and comprehensive reference on ligand-binding assays Ligand-binding assays (LBAs) stand as the cornerstone of support for definition of the pharmaco-kinetics and toxicokinetics of macromolecules, an area of burgeoning interest in the pharmaceutical industry. Yet, outside of the Crystal City Conference proceedings, little guidance has been available for LBA validation, particularly for assays used to support macromolecule drug development. Ligand-Binding Assays: Development, Validation, and Implementation in the Drug Development Arena answers that growing need, serving as a reference text discussing critical aspects of the development, validation, and implementation of ligand-binding assays in the drug development field. Ligand-Binding Assays covers essential topics related to ligand-binding assays, from pharmacokinetic studies, the development of LBAs, assay validation, statistical LBA aspects, and regulatory aspects, to software for LBAs and robotics and other emerging methodologies for LBAs. Highlights include: A general discussion of challenges and proven approaches in the development of ligand-binding assays More detailed examination of characteristics of these assays when applied to support of pharmacokinetic and toxicokinetic studies of compounds at different stages in the discovery or development timeline A concise, but detailed, discussion of validation of ligand-binding assays for macromolecules A practical approach to «fit-for-purpose» validation of assays for biomarkers, those molecules receiving increased attention as potentially demonstrating that the target chosen in discovery is being modulated by the candidate therapeutic, both in nonclinical and clinical studies Written by a team of world-recognized authorities in the field, Ligand-Binding Assays provides key information to a broad range of practitioners, both in the pharmaceutical and allied industries and in related contract research organizations and academic laboratories and, perhaps, even in the field of diagnostics and clinical chemistry.

While the success of Open Source software like Linux or Apache has been documented extensively throughout all mainstream media, the rise of PHP has gone largely unnoticed. Still, the Web scripting language PHP is the most popular module for the Apache Web server, according to an E-Soft survey (www.e-softinc.com/survey/). Netcraft studies have found that PHP is in use on over 6% of all Web domains in the world (see www.netcraft.com/survey).That’s an incredible market penetration for a rather specialized product.This popularity continues to rise exponentially. Increasingly, this is being reflected in traditional media: As of May, 2000, more than 20 books about PHP have been published in different languages, with more in the pipeline. Commercial players are beginning to join the bandwagon: PHP is included with Web servers, for example C2’s Stronghold, and Linux distributions. A new company, Zend Technologies, has been formed to provide commercial add-ons and support for PHP.A long list of large-scale Web sites employ PHP, as well as hundreds of thousands of small to medium Web sites.

The personal home page (PHP) server-side scripting language is particular well adapted to connecting HTML-based web pages to a backend database for dynamic content. This book explains the entire nuts-and-bolts process of the PHP application life cycle: requirements, design, development, maintenance and tuning. It shows how PHP can be used to design and develop highly manageable and secure applications to solve practical problems.

Existentialism proclaims the idea of a man present, performing a search for meaning, making choices, self-determining in its relation to reality, possessing an active subjective entity. In the process of economic activity a person is faced with the action of their own will influence other areas of the will of the active agents. He needs arise that require his satisfaction, he is involved in the economic cycle, some of which sectors are investigated in this study, namely: entrepreneurship, as a consequence of the implementation of a new combination of natural factors, business risk as a source of entrepreneurial profit and a catalyst for economic activity, business as routine economic activities aimed at developing the existing building, international business, as economic activity is possible at a potential that is created by public constraints, international payments, as the movement of financial resources for a business, writ proceedings, as inevitable, the procedure of execution of mutual obligations with the participation of the public entity, collateral relations, as security relationships that create a safety buffer for the counterparty.

Having just escaped from the treacherous island that was once Manhattan, Brooke, Ben, Logan, Bree and Rose make their way up the Hudson river in their stolen boat, low on fuel, low on food, and desperately needing shelter from the cold. On their tails are the slaverunners, who will stop at nothing until they capture them and bring them back. As they make their way upriver in this post-apocalyptic, action-packed thriller, on their way to try to find the mythical city in Canada, they will need to use all their ingenuity and survival skills to stay alive. Along the way they will encounter crazed survivors, roving gangs of predators, cannibals, wild animals, a desolate wasteland, and an unstoppable blizzard. They sustain injuries, get sick, and the Hudson freezes over as they do their best to salvage what they can and avoid the slaverunners' pursuit. They find a small island and think they have found respite – until events don't go their way. It is not until they board a mysterious train to nowhere that they find that things can always get worse. Along the way, Brooke's feelings for Logan intensify, as do her feelings for Ben. Torn between these two boys, caught between their jealousy, she is unsure how she feels – until events choose for her. As they find themselves thrown back into an arena, they are shocked to discover that Arena Two is even worse. Thrown into a barbaric fighting stage, equipped with weapons, pitted against other teenagers – and against themselves – Brooke and the others will be forced to choose what's important, and to make the most difficult sacrifices of their lives. Because in Arena Two, no one survives. Ever.