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This comprehensive, clinically-grounded textbook, now in its fourth edition, supports orthoptists and ophthalmologists in decision-making through the patient care process, from presentation to discharge. Written by authors with extensive experience in teaching and research, Diagnosis and Management of Ocular Motility Disorders offers a clear and practical overview of assessment and management principles and further explores the clinical features of specific disorders, from amblyopia and infantile strabismus to supranuclear and infranuclear disorders, as well as other miscellaneous disorders of ocular movement. A brand new chapter on congenital cranial dysinnervation disorders reflects recent advances in gene mapping and increased understanding of this condition, and a new appendix provides surgical dose tables for easy reference. Now in full colour throughout, with additional diagrams and photographs of surgical techniques, this remains the key reference text for orthoptic and ophthalmic professionals managing patients with eye movement disorders.

The aim of this book has always been to give guidance on the diagnosis and treatment of ocular motility disorders based on clinical experience, as opposed to a comprehensive treatise on the subject drawn from the primary literature. The Third Edition sees a new team of authors who have kept very much to this priniciple in their nevertheless thorough revision of the book. Whilst there are no new chapters as such, the immediate impact of the revision is in the improved page layout with increased use of diagrams and flowcharts. There are new sections on feigned visual loss in adults and children, the management of residual defects and the section on botulinum toxin treatment in chapter 8 will be re-written to take account of the great advances in this form of treatment.

This book features contributions from experts in cell biology, genetics, neurobiology, immunology and structural biology. The unifying element is that they all study processes of cell shape change and motility. Several key questions in this field of research are discussed: What are the organising principles behind cell shape change? Are there ‘master switches’ present in every cell type? How are extracellular signals interpreted by the cell in order to activate intracellular mechanisms? What is the influence of the extracellular matrix on cell movement and internal signalling pathways? How do pathogens subvert cellular systems in order to stimulate or block their uptake? The book addresses all of these important questions. Data are presented on the key proteins that regulate cell shape: the GTP binding proteins of the Rho family. There are also extensive discussions of the potential applications of the data to clinical problems, particularly that of cell motility in cancer.

Recent advances in molecular and biophysical techniques, particularly fluorescence and live cell imaging, are revolutionizing the study of cell motility. New bioprobes not only reveal simple intracellular localization, but also contain details of post-translational modifications, conformational state and protein-protein interactions. Coupling these insights with complementary advances in genetic and biochemical methods is enabling scientists to understand the processes involved in cell motility – from molecular motors to cell movements in vivo in a range of organisms and cell types. This book features landmark essays that provide an up to date and fascinating account of current research and concepts in cell motility.These cover the roles of molecular motors that drive movement and their interactions with the cytoskeleton as well as membrane dynamics that allow cells to change shape and to move. Cell motility plays a key role in development – there are chapters on the genetics of cell migration, the regulation of contact repulsion in growth cones, and the progression from cell migration to cell-cell adhesion. Cell motility is directional – experts describe the molecules that regulate chemotaxis, allowing cells to migrate along pathways specified by chemical gradients. Finally, cell motility can be perturbed by mutation–metastasis occurs when cells lose their normal intercellular interactions and invade other tissue types. All these processes are regulated by signals from the environment, including other tissues in the body, and the various molecules that transmit and transduce these signals are discussed. This book is a 'must read' for cell biologists working in a variety of fields, from development to wound healing, at all levels – post-doctoral fellows, post-graduate students and lab technicians. It is also stimulating reading for molecular and developmental biologists, biophysicists and biochemists.