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Functional neurosurgery resource features state-of-the-art approaches from renowned experts! For patients with inadequately treated epilepsy, tremor, dystonia, spasticity, depression, obsessive-compulsive disorder, Parkinson's and Alzheimer's disease, functional neurosurgery offers hope. Functional Neurosurgery: The Essentials is a reader-friendly introduction to this fascinating and rapidly evolving field. The text is edited by internationally prominent functional neurosurgeons Jeffrey A. Brown, Julie G. Pilitsis, and Michael Schulder. It features contributions from authors with expertise spanning the disciplines of neurosurgery, neurology, rehabilitation and physical medicine, neurophysiology, bioengineering, psychiatry and ophthalmology. Opening with a brief history of stereotaxy/functional neurosurgery and brain stereotactic frames, 41 concise and coherent chapters explore cutting-edge approaches to a broad range of functionally treatable conditions. The chapters yield a solid foundation of understanding of the field, with insightful commentary, pearls, and nuances from the editors. The starting question in the neuroprosthetics chapter, «Can a computer infer human intention or perception?» brings to life the exciting, inquisitive, and pioneering spirit of this subspecialty. The robust reference list provides a guide to deeper study that should continue throughout training and practice. Highlights Imaging: MRI and CT for stereotactic neurosurgery, fMRI and resting state MRIMovement disorders: A comparative analysis of the risks and benefits of deep brain stimulation versus lesioningEpilepsy: Temporal lobectomy and extra-temporal surgery; invasive monitoring, neuromodulation, laser interstitial thermal therapy, and vagus nerve stimulationDystonia: Etiology to diagnosis, medical and surgical optionsFuture innovations: Exoskeletons, intention controlled, and visual neuroprosthetics The text is a fundamental resource for neurosurgical residents during their functional neurosurgery rotations and for general neurosurgeons and functional subspecialists on procedures they may not routinely perform in clinical practice.

In a world of fierce global competition and rapid technological change, traditional strategies for gaining market share and achieving efficiencies no longer yield the returns they once did. How can companies drive consumer preference and secure sustainable growth in this digital, social, and mobile age? The answer is through functional integration. Some of the world's most highly valued companies—including Amazon, Apple and Google—have harnessed this new business model to build highly interactive ecosystems of interrelated products and digital services, gaining new levels of customer engagement. Functional integration offers forward-looking brands a unique competitive edge by using transformative digital technologies to deliver high-value customer experiences, generate repeat business, and unlock lucrative new business-to-business revenue streams. Connected By Design is the first book to show business leaders and marketers exactly how to use functional integration to achieve transformative growth within any type of company. Based on R/GA's pioneering work with firms at the forefront of functional integration, Barry Wacksman and Chris Stutzman identify seven principles companies must follow in order to create and deliver new value for customers and capture new revenues. Connected By Design explains how functional integration drove the transformation of market-leading companies as diverse as Nike, General Motors, McCormick & Co., and Activision to establish authentic brand relationships with their customers, enter new categories, and develop new sources of income. With Connected by Design, any company can leverage technological disruption to redefine its mission and foster greater brand loyalty and engagement.

Take advantage of the growing trend in functional programming. C# is the number-one language used by .NET developers and one of the most popular programming languages in the world. It has many built-in functional programming features, but most are complex and little understood. With the shift to functional programming increasing at a rapid pace, you need to know how to leverage your existing skills to take advantage of this trend. Functional Programming in C# leads you along a path that begins with the historic value of functional ideas. Inside, C# MVP and functional programming expert Oliver Sturm explains the details of relevant language features in C# and describes theory and practice of using functional techniques in C#, including currying, partial application, composition, memoization, and monads. Next, he provides practical and versatile examples, which combine approaches to solve problems in several different areas, including complex scenarios like concurrency and high-performance calculation frameworks as well as simpler use cases like Web Services and business logic implementation. Shows how C# developers can leverage their existing skills to take advantage of functional programming Uses very little math theory and instead focuses on providing solutions to real development problems with functional programming methods, unlike traditional functional programming titles Includes examples ranging from simple cases to more complex scenarios Let Functional Programming in C# show you how to get in front of the shift toward functional programming.

Small structural modifications can significantly affect the pharmacokinetic properties of drug candidates. This book, written by a medicinal chemist for medicinal chemists, is a comprehensive guide to the pharmacokinetic impact of functional groups, the pharmacokinetic optimization of drug leads, and an exhaustive collection of pharmacokinetic data, arranged according to the structure of the drug, not its target or indication. The historical origins of most drug classes and general aspects of modern drug discovery and development are also discussed. The index contains all the drug names and synonyms to facilitate the location of any drug or functional group in the book. This compact working guide provides a wealth of information on the ways small structural modifications affect the pharmacokinetic properties of organic compounds, and offers plentiful, fact-based inspiration for the development of new drugs. This book is mainly aimed at medicinal chemists, but may also be of interest to graduate students in chemical or pharmaceutical sciences, preparing themselves for a job in the pharmaceutical industry, and to healthcare professionals in need of pharmacokinetic data.

A multidisciplinary approach that explores the diverse properties, functions, and applications of nanomaterials Drawing together the many scientific and engineering disciplines underlying the development of nanomaterials, Nanoscale Multifunctional Materials provides a multidisciplinary review of the diverse properties, functions, and applications of nanomaterials. The book examines both nanoparticles, which have larger-scale equivalents, and uniquely assembled nanomaterials, which do not have larger-scale equivalents. Readers will gain a tremendous appreciation of the versatility of nanomaterials as well as an understanding of how the same nanomaterial can have several distinct applications across a broad range of fields and industries. Nanoscale Multifunctional Materials is divided into three sections: ? Section I, Overview, describes the scientific phenomena underlying the special properties of nanomaterials, making them desirable as novel materials and different from conventional solids. Next, readers will learn about the effect of nanomaterials on contemporary society as well as future trends in nanomaterials production and use. ? Section II, Processing and Analysis, explores several experimental approaches in nanomaterial fabrication and characterization as well as in theoretical approaches in modeling and simulation. ? Section III, Applications, offers detailed examples of nanomaterial applications in alternative energy, thermal management, environmental cleanup, water treatment, and biomedicine. Each chapter has been written by one or more leading experts in the science, engineering, and application of nanomaterials. Within each chapter, readers will find a thorough review of the current literature, with references to facilitate further investigation of individual topics. Underscoring the multidisciplinary and multifunctional characteristics of nanomaterials, this book is recommended for students and professionals in science and engineering who need a broad perspective on both the nature and application of nanomaterials. The text also sets the stage for the development of new nanomaterials and new applications.

Functionalized Inorganic Fluorides: Synthesis, Characterization & Properties of Nanostructured Solids covers several classes of nanostructured and functionalized inorganic fluorides, oxide-fluorides, and fluorinated oxides such as silica and alumina. Ranging from powders or glass-ceramics to thin layers and coatings, they have applications as more efficient and less aggressive catalysts, UV absorbers, planar optical waveguides, integrated lasers and optical amplifiers, luminescent materials, anti-reflective coatings and high Tc superconductors. With a focus on new types of solids, such as nanopowders, hybrids, mesoporous fluorides, and intercalation compounds, the book covers new synthesis routes; physical-chemical characterizations – including morphology, structure, spectroscopic and optical behaviour; detailed ab initio investigations and simulations; and -last but not least- potential applications.